pH-Dependent Configurations of a 5-Chlorouracil-Guanine Base Pair
نویسندگان
چکیده
منابع مشابه
The deprotonated guanine-cytosine base pair.
Awareness of the harmful effects of radiation has increased interest in finding the mechanisms of DNA damage. Radical and anion formation among the DNA base pairs are thought to be important steps in such damage [Collins, G. P. (2003) Sci. Am. 289 (3), 26-27]. Energetic properties and optimized geometries of 10 radicals and their respective anions derived through hydrogen abstraction from the W...
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Prebiotic chemistry presumably took place before formation of an oxygen-rich atmosphere and thus under conditions of intense short wavelength UV irradiation. Therefore, the UV photochemical stability of the molecular building blocks of life may have been an important selective factor in determining the eventual chemical makeup of critical biomolecules. To investigate the role of UV irradiation ...
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The thymine analog 5-chlorouridine, first reported in the 1950s as anti-tumor agent, is known as an effective mutagen, clastogen and toxicant as well as an effective inducer of sister-chromatid exchange. Recently, the first microorganism with a chemically different genome was reported; the selected Escherichia coli strain relies on the four building blocks 5-chloro-2'-deoxyuridine (ClU), A, C a...
متن کاملANALYSIS OF THE pH-DEPENDENT EQUILIBRIUM RELATIONSHIP BETWEEN THE GUANINE OXIDATION PRODUCTS 5-GUANIDINOHYDANTOIN AND IMINOALLANTOIN
Oxidation of 2’-deoxyguanosine (dG) results in the major two-electron product 8oxo-7,8-dihydro-2’-deoxyguanosine (dOG) that can undergo further oxidation to other products. One such product is 5-guanidinohydantoin (dGh) that is highly mutagenic and has been found in vivo. The ring architecture of dGh is similar to allantoin, an oxidation product of uric acid. Allantoin establishes equilibrium b...
متن کاملGuanine- 5-carboxylcytosine base pairs mimic mismatches during DNA replication
The genetic information encoded in genomes must be faithfully replicated and transmitted to daughter cells. The recent discovery of consecutive DNA conversions by TET family proteins of 5-methylcytosine into 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine (5caC) suggests these modified cytosines act as DNA lesions, which could threaten genome integrity. Here, we have shown tha...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 2009
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi901154t